Advice Needed for Custom PC Build for Research and Gaming

Hey everyone! I'm gearing up to build my first PC after a decade without one, and I really need your input! I want a powerhouse machine that can process large mass spectrometry datasets, handle computational chemistry tasks, and manage all the number-crunching research activities I do. At the same time, I want it to run the latest games smoothly with great graphics and be future-proof for a VR setup down the line. I've started putting together a build and would love your advice on it. I'm also open to any tips on the building process itself! Thanks a ton for your help!