Would these PC specs run Genshin Impact smoothly?

It should be capable of playing Genshin, though smooth performance at every setting isn't guaranteed. The GTX 1060 is an older card, and this is the 3GB version, so its limited video memory may mean turning down graphics settings.

I'd start at 1080p with moderate settings and adjust if you get slowdowns. More demanding areas, including the Sumeru desert, may run less smoothly than others.

The 16GB of RAM and SSD are nice to have for this game. The main thing to check is that the listing has a working GTX 1060, not just the integrated graphics built into the 2400G. Ask to see the game running on the PC before buying if that's possible.

For $325, it looks like a reasonable used PC rather than an amazing bargain. The processor and graphics card are dated, but the B450 motherboard gives you some upgrade options later. Whether it's a good buy still depends on the condition of the parts.

Also check the Windows situation. The listing says Windows 10, so consider support and whether the machine can meet Windows 11 requirements before relying on it long term.

It could be a big step up from your laptop, especially if the laptop only has integrated graphics. Without knowing the laptop's CPU and graphics, though, it's hard to say how big the difference would be.