About two weeks ago I powered down my computer and cleaned it with compressed air and a vacuum. Since then, my printer, webcam, and scanner randomly disconnect when plugged into the rear USB ports—sometimes within 10 minutes of startup, sometimes after several hours. I've tried different ports and cables, cleaned the connectors, checked for bent pins or corrosion, tested other devices and power sources, gently moving the cables, and leaving the computer completely unplugged for eight hours. None of that helped, and the disconnects seem to be becoming more frequent. I also noticed that my wireless mouse lags when connected to the blue USB ports but works normally from the teal/cyan ports. Disabling USB power-saving options in Device Manager and system settings made no difference. What could be causing this, and how can I determine whether the motherboard or individual USB ports were damaged?
3 Answers
A vacuum can create static electricity, so an electrostatic discharge may have damaged part of the motherboard’s USB circuitry. The fact that several devices disconnect while certain port groups behave differently points more toward a USB controller or motherboard issue than three bad peripherals. Test with only a basic keyboard and mouse connected, then add the other devices back one at a time. If the same port group remains unreliable, the practical fixes are using the stable ports, adding a PCIe USB expansion card, or replacing the motherboard.
USB ports are often divided between multiple controllers and power hubs. The blue ports may be USB 3.x, while the teal/cyan ones could be connected differently, which would explain why the mouse behaves better there. Try installing the latest chipset and USB drivers from the motherboard manufacturer, then check whether the failures happen only on one controller or group of ports. Also inspect the motherboard for a slightly loose internal USB header or dust around the rear I/O area.
Disconnect everything except the keyboard and mouse and leave the system running for several hours. Reconnect the printer, webcam, and scanner individually, waiting between tests. If one device causes the issue, its cable or power draw may be the trigger. If the disconnect sound still happens with only one known-good device, boot from a Linux live USB or another operating system; if the problem continues there, Windows power settings are not the cause and the motherboard’s USB hardware is the likely culprit.
Moving devices between ports is useful, but it doesn’t fully isolate the problem when several ports share the same controller. Testing one device at a time and then trying a separate USB expansion card should make that distinction clearer.

I tested the computer at another location with different peripherals and it worked normally there, but I’m still not sure whether that rules out damage to my original devices or cables.