I'm using an ASUS ProArt X870E-CREATOR WIFI motherboard with a Ryzen 9 9950X3D CPU and I'm struggling to get my 4x32GB G.Skill Trident Z5 Neo DDR5-6000 RAM stable beyond DDR5-4800. I've tested both 2x32GB kits individually, and they pass Memtest86+ at DDR5-6000 without errors, but when I try all four DIMMs together, training fails and I end up in safe mode. I've attempted various configurations, including EXPO profiles and manual settings, but the best stability I get is at DDR5-4800. Has anyone gotten similar setups stable above that speed on this board? Any recommendations for timing adjustments or specific voltage settings? Also, is the DDR5 Timing Calculator worth using for this issue? Stability is my priority since I'm running Proxmox as a hypervisor, so I'm okay with lower speeds as long as it's reliable. Thanks for any insights!
3 Answers
If you’re looking to stabilize things, consider going for lower clock speeds like DDR5-5200 with looser timings. It might be better for reliability as opposed to pushing for the highest speed. Also, don’t forget to play around with the voltage settings if things still seem off—sometimes a small tweak can make a big difference.
Overclocking all four sticks of DDR5 can be tricky, especially with AMD CPUs. If your RAM isn't on the motherboard's QVL, that could be part of the issue. I had a similar problem with my setup; sometimes, it might work best with sticks that are listed for compatibility. If you haven't tried it yet, consider backing off the timings a bit. That might just help stabilize your system.
I've gotten my 4x48GB sticks stable at 6000MT EXPO by tweaking the VDDQ and VDDIO voltages lower while keeping other settings stock. I bought two identical kits so that might've helped. You mentioned having different kits, which may cause issues if their specs don’t perfectly align. Try to place the sticks from the same kit in the same memory channels, like A1 and A2 for one kit, B1 and B2 for the other. Also, make sure your BIOS is up-to-date—I’ve read that ASUS has improved 4 DIMM setups with newer versions.
Great tips! I’ll make sure to check that and place the sticks accordingly. My BIOS is already on the latest version, so fingers crossed!

Yeah, I didn’t think about the QVL factor. I’ll ease up on the timings and see if that helps.