I currently have 2x16GB RAM sticks, and I'm considering adding 2x32GB sticks of the same model to my setup. My CPU is a 7600X, and I'm using a B650M-A motherboard. I'm curious about the compatibility issues, especially since I'll be using this for intensive local AI work and video editing. Would this mix of RAM sizes and the specs work together without issues?
5 Answers
Honestly, I've never seen anyone successfully use such a mix. My advice? Just stick with the 2x32GB RAM instead.
Mixing different sizes of RAM can be tricky, especially on AM5 platforms. If it boots, you're lucky, but you might struggle to get XMP profiles running due to the mixed DIMMs. For better stability, it’s often recommended to have identical pairs in each channel, which won't work well here because of the different sizes. You might be better off with a complete kit like 2x48GB or 2x64GB and selling your current sticks.
You should only use 2 sticks at a time; that's what the 7600X really supports best. Using four sticks at higher speeds is more problematic, especially when they’re different types.
I've mixed RAM in the past with DDR4 successfully, but I've heard that DDR5 might not cooperate as well. There’s definitely a risk it won’t work, so approach with caution.
It could work, just be sure to install the matched pairs in the same channel. Some setups struggle with four sticks at higher speeds, meaning you might have to lower the RAM speed. Just keep that in mind as it could affect performance.

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