I'm using an MSI MAG B850 Tomahawk Max motherboard paired with a Ryzen 9 9900X and I'm curious if it's feasible to run 4 sticks of 16GB RAM at 6000MHz without issues. Has anyone had experience with this setup?
4 Answers
I've successfully run 4x16GB at 6000MHz with the FCLK set to 2000 and MCLK/UCLK at 3000. However, when I switched to four sticks from just two, I noticed I couldn't reach my previous speeds of 6400/2133/3200 anymore. Just a heads-up—four single-rank sticks can work, but your experience may vary.
It's pretty unlikely that all four sticks will actually run at 6000 MT/s. Usually, you might get them to run, but probably at a slower speed.
I've got a 9950X3D and I run four 16GB Crucial DDR5 Pro sticks at 6400 MT/s CL38, but I had to set the timings manually in the BIOS since the EXPO profile didn’t work for me. It actually runs pretty stable, and I've seen a nice boost in benchmarks. But I used to own a MSI board where it would crash and BSOD often at those speeds, so I'd say your MSI board might not be the best choice for this setup.
If you’re running four sticks, the EXPO profile might not be compatible. AMD officially only supports running four sticks at 3600 MT/s for Ryzen 9000 CPUs. Anything higher becomes a bit of a lottery with silicon quality.

It's interesting you say that, because Wendell from Level1Techs found that MSI boards performed really well with certain 4x64GB kits in his testing. So maybe there’s some context-dependent performance to consider here!