After replacing my RX 6800 XT with an ASUS Radeon RX 9070 XT, Windows 11 becomes nearly unusable immediately after logging in. I can move the mouse, but clicks do not open applications or interact with the desktop. Task Manager, Settings, and the normal restart menu are also inaccessible, so I have to hold the physical power button to shut the computer down.
I booted into Safe Mode and used Display Driver Uninstaller to remove the previous graphics drivers before installing the 9070 XT drivers. That fixed the problem temporarily, but it returned after the next shutdown. System Restore behaved the same way: everything worked until I powered the PC off and started it again. I have also updated the motherboard BIOS and chipset drivers without resolving the issue.
The system contains a Ryzen 7 7700, MSI MAG B650 TOMAHAWK WIFI, ASUS Prime RX 9070 XT, 32GB of Corsair Vengeance DDR5, a Corsair RM850x (2024) power supply, and Crucial P3 Plus 1TB plus WD Black SN770 2TB NVMe drives. Has anyone encountered this after a GPU upgrade, or know what could cause Windows to stop accepting desktop clicks during startup?
3 Answers
If you previously tuned the 6800 XT in AMD Adrenalin, remove any saved tuning profiles and reset the driver settings before testing again. A clean driver installation should normally clear them, but it is worth checking. Also verify that the motherboard BIOS is fully current and that there are no known compatibility problems with the specific 9070 XT model.
Check the BIOS display settings, especially the integrated graphics or UMA option. On this platform, leaving integrated graphics on Auto may cause Windows and the new discrete GPU to initialize in an unexpected way. Setting the integrated graphics option to Default instead of UMA Auto fixed the problem for me, at least so far.
Since the pointer still moves, try another mouse or use the keyboard-based mouse controls to rule out a faulty mouse or USB input problem. However, if multiple input devices behave the same way, the issue is probably related to the graphics configuration rather than the mouse itself.
The mouse moves normally, but clicking applications does nothing. I found that disabling integrated graphics in the BIOS temporarily restored normal desktop behavior.

Changing Integrated Graphics from UMA Auto to Default appears to have fixed it so far. I am going to test several shutdown and startup cycles to make sure the change persists.