I'm in the process of setting up FSLogix for profile management on some RDS session hosts. I'm planning to create new profiles using VHDX files, and the storage is on an HPE Alletra SAN. From what I've gathered, it's suggested to format the virtual disk containing the profile containers to 4096 bytes and set the Group Policy Objects (GPOs) to use VHDX and also a sector size of 4096. However, I'm thinking of sticking with NTFS rather than using ReFS, since I've heard others have faced problems with ReFS when storing profiles. So my main question is: Is it beneficial to go with a 4K sector size using NTFS instead of ReFS? Does it really make a difference? Thanks!
4 Answers
Alignment of sector sizes is crucial for spinning drives, but with flash storage, it’s less of an issue. For your VHDX files, choose the largest efficient sector sizes supported by your SAN. Also, do some performance benchmarking since CPU and network factors play a role too.
Definitely go with NTFS. ReFS can cause problems when it decides to act up, so you don't want to deal with that mess. Keep it simple and stick with NTFS for your profiles.
I’d suggest using NTFS for the volume holding the VHDX files, but consider going with 64KB clusters instead of 4KB. Going with 4KB can limit your volume size to 16TB, and larger clusters are usually more efficient for bigger data chunks.
I recommend using NTFS as well. Honestly, configuring sector sizes isn't necessary unless Microsoft specifically advises it, so leaving it at default is the way to go.

Related Questions
Can't Load PhpMyadmin On After Server Update
Redirect www to non-www in Apache Conf
How To Check If Your SSL Cert Is SHA 1
Windows TrackPad Gestures