What’s the Best Antivirus for Running Wine Programs?

While ClamAV often gets called out for its low detection rate, another issue is its weak real-time monitoring. Most Windows antivirus solutions handle real-time scanning really well, but ClamAV falls short in comparison and can flag a lot of false positives. That said, it's decent for running periodic scans. If your software comes from trusted sources like your package manager, you usually don't have much to worry about, but if you do need to run risky stuff, consider using a VM for testing.

If you're unsure about a file, try uploading it to VirusTotal. It's a quick way to scan a file for potential threats before running it. Just keep in mind that larger programs might take some time since there's a file size limit for uploads, especially if you're looking at something like a big game.

Remember, malware can appear on any OS, so always treat unknown files as potential threats. Instead of relying on antivirus, consider using a sandbox to test unknown applications. It adds a layer of security without the inherent risks that some antivirus programs can carry.