How can I safely run Windows games on my Linux system without getting viruses?

Stay clear of third-party antivirus programs unless you really trust them. Avast is okay, but Windows Defender is often enough. One big tip is to be cautious with zipped files that require passwords. Those can be tricky for antivirus software to scan before you extract them.

The simplest way to avoid malware is just not to download unsafe files. Be mindful of what you're installing and where it's coming from.

If you're using Bottles, it actually sandboxes Wine, which helps protect your system from Windows malware. Just remember, that malware typically goes after browsers, and if you're careful not to install any browsers in your Bottles setup, you mitigate that risk. If you ever suspect an infection through Wine, just deleting your Wine prefix is usually enough.

The best way to protect yourself is to avoid running untrusted software. Always try to use software from reliable sources, like Steam or the official package manager for your Linux distribution. The good news is that Windows malware usually doesn't work on Linux, so the risk is lower. Honestly, I don't use antivirus on my Linux systems, and I think many others don't either.